Asymmetric hydrogenation is playing a major role in the creation of chiral centers, and is widely used on a research and industrial production scale. Some of the most common ligands for asymmetric hydrogenation are C2-symmetrical phosphines, of which the most notable ones are BINAP, DIPAMP, or TADDOL. Zhou and co-workers have developed a new type of C2-symmetrical ligand with 1,1'-spirobi-indane as backbone, and which offers higher enantiocontrol. It has shown excellent reactivity and selectivity in a variety of asymmetric hydrogenations. Aldrich is pleased to offer a library of these new ligands.
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