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Polymer‐coated viral vectors: hybrid nanosystems for gene therapy

机译：聚合物涂层病毒载体：用于基因疗法的杂化纳米系统

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Abstract >The advantages and critical aspects of nanodimensional polymer‐coated viral vector systems potentially applicable for gene delivery are reviewed. Various viral and nonviral vectors have been explored for gene therapy. Viral gene transfer methods, although highly efficient, are limited by their immunogenicity. Nonviral vectors have a lower transfection efficiency as a result of their inability to escape from the endosome. To overcome these drawbacks, novel nanotechnology‐mediated interventions that involve the coating or modification of virus using polymers have emerged as a new paradigm in gene therapy. These alterations not only modify the tropism of the virus, but also reduce their undesirable interactions with the biological system. Also, co‐encapsulation of other therapeutic agents in the polymeric coating may serve to augment the treatment efficacy. The viral particles can aid endosomal escape, as well as nuclear targeting, thereby enhancing the transfection efficiency. The integration of the desirable properties of both viral and nonviral vectors has been found beneficial for gene therapy by enhancing the transduction efficiency and minimizing the immune response. However, it is essential to ensure that these attempts should not compromise on the inherent ability of viruses to target and internalize into the cells and escape the endosomes. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”xml：lang =“en”> <标题类型=“main”>摘要</ title> >可能适用于基因递送的纳米二维聚合物涂层病毒载体系统的优点和关键方面是审查。已经探索了各种病毒和非血管载体用于基因治疗。病毒基因转移方法虽然高效，受到其免疫原性的限制。由于无法逃离内体，非血管载体具有较低的转染效率。为了克服这些缺点，新的纳米技术介导的干预们涉及使用聚合物涂覆或改性病毒的介导的干预措施在基因治疗中被出现为新的范例。这些改变不仅改变了病毒的热衷，而且还减少了与生物系统的不希望的相互作用。而且，聚合物涂层中的其他治疗剂的共封装可用于增加治疗效果。病毒颗粒可以帮助内体逸出，以及核靶向，从而提高转染效率。通过提高转导效率并最小化免疫应答，已经发现，已经有利于基因治疗的理想性质的整合。然而，必须确保这些尝试不应妥协病毒靶向的固有能力和内化到细胞中并逃逸内体。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-30882/'>《The journal of gene medicine》</a> <b style="margin: 0 2px;">|</b><span>2018年第4期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rajagopal Pratheppa&option=202" target="_blank" rel="nofollow">Rajagopal Pratheppa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Duraiswamy Sowmiya&option=202" target="_blank" rel="nofollow">Duraiswamy Sowmiya;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sethuraman Swaminathan&option=202" target="_blank" rel="nofollow">Sethuraman Swaminathan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Giridhara Rao Jayandharan&option=202" target="_blank" rel="nofollow">Giridhara Rao Jayandharan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Krishnan Uma Maheswari&option=202" target="_blank" rel="nofollow">Krishnan Uma Maheswari;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Centre for Nanotechnology &</p> <p>Advanced Biomaterials (CeNTAB)SASTRA Deemed‐to‐be UniversityThanjavur India;</p> <p>Centre for Nanotechnology &</p> <p>Advanced Biomaterials (CeNTAB)SASTRA Deemed‐to‐be UniversityThanjavur India;</p> <p>Centre for Nanotechnology &</p> <p>Advanced Biomaterials (CeNTAB)SASTRA Deemed‐to‐be UniversityThanjavur India;</p> <p>Department of Biological Sciences and BioengineeringIndian Institute of TechnologyKanpur Uttar Pradesh India;</p> <p>Centre for Nanotechnology &</p> <p>Advanced Biomaterials (CeNTAB)SASTRA Deemed‐to‐be UniversityThanjavur India;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1473.html" title="医学遗传学">医学遗传学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=immune response&option=203" rel="nofollow">immune response;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nanoparticles&option=203" rel="nofollow">nanoparticles;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nonviral vector&option=203" rel="nofollow">nonviral vector;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=viral vector&option=203" rel="nofollow">viral vector;</a> </p> <div class="translation"> 机译：免疫反应;纳米颗粒;非血载体;病毒载体; 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