'Managing' the Placebo Effect: The Single-Blind Placebo Lead-in Response in Two Pain Models

摘要

Objective. "Placebo effects" in analgesic medication trials for chronic pain are pervasive; however, little is known regarding mechanisms or factors that may influence the presence or magnitude of these effects. Our objective is to consider elements of the placebo response in the context of two pain models using a "single-blind placebo lead-in" design (SBPLI).