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Tissue Engineering of Large Full-Size Meniscus Defects by a Polyurethane Scaffold: Accelerated Regeneration by Mesenchymal Stromal Cells

机译:聚氨酯支架的大型全尺寸弯月面缺陷组织工程:间充质基质细胞加速再生

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摘要

The endogenous healing potential of avascular meniscal lesions is poor. Up to now, partial meniscectomy is still the treatment of choice for meniscal lesions within the avascular area. However, the large loss of meniscus substance predisposes the knee for osteoarthritic changes. Tissue engineering techniques for the replacement of such lesions could be a promising alternative treatment option. Thus, a polyurethane scaffold, which is already in clinical use, loaded with mesenchymal stromal cells, was analyzed for the repair of critical meniscus defects in the avascular zone. Large, approximately 7 mm broad meniscus lesions affecting both the avascular and vascular area of the lateral rabbit meniscus were treated with polyurethane scaffolds either loaded or unloaded with mesenchymal stromal cells. Menisci were harvested at 6 and 12 weeks after initial surgery. Both cell-free and cell-loaded approaches led to well-integrated and stable meniscus-like repair tissue. However, an accelerated healing was achieved by the application of mesenchymal stromal cells. Dense vascularization was detected throughout the repair tissue of both treatment groups. Overall, the polyurethane scaffold seems to promote the vessel ingrowth. The application of mesenchymal stromal cells has the potential to speed up the healing process.
机译:缺血性半月板病变的内源性愈合潜力差。到目前为止,部分裂缝切除术仍然是养血区内半月板病变的选择。然而,弯月面物质的大损失易于膝关节骨质骨质变化。用于更换这种病变的组织工程技术可能是一个有前途的替代治疗选择。因此,分析了已经临床使用的聚氨酯支架,其含有间充质基质细胞,用于修复养血区中的临界弯月面缺陷。大约7毫米的宽半月板病变,影响横向兔弯月面的缺血和血管面积的用聚氨酯支架处理,用于用间充质基质细胞卸载。初始手术后6和12周收获了半月核。无论是无电池和电池加载的方法都导致良好的整合且稳定的弯月面修复组织。然而,通过施用间充质基质细胞来实现加速愈合。在整个治疗组的修复组织中检测到致密血管化。总的来说,聚氨酯支架似乎促进了血管内血管。间充质基质细胞的应用具有加速愈合过程的潜力。

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  • 来源
    《Stem cells international》 |2018年第3期|共11页
  • 作者单位

    Univ Med Ctr Regensburg Dept Trauma Surg Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

    Univ Med Ctr Regensburg Dept Trauma Surg Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

    Univ Med Ctr Regensburg Dept Trauma Surg Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

    Univ Med Ctr Regensburg Dept Trauma Surg Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

    Univ Med Ctr Regensburg Dept Trauma Surg Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

    Univ Med Ctr Regensburg Dept Trauma Surg Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

    Univ Med Ctr Regensburg Dept Trauma Surg Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

    Univ Med Ctr Regensburg Dept Trauma Surg Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

    Univ Med Ctr Regensburg Dept Trauma Surg Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物工程学(生物技术);
  • 关键词

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