So far, it is not possible to completely eradicate HIV in infected individuals because the virus can hide away in a latent form in CD4~+ T cells, where it is invisible to immune cells. A number of 'shock-and-kill' strategies that aim to reactivate the virus, followed by drug or immune-mediated clearance of infected cells, have been tested, with limited success. Now, back-to-back reports in Nature describe two different approaches to induce robust and reproducible disruption of HIV latency.
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