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Materials for flexible bioelectronic systems as chronic neural interfaces

机译:柔性生物电子系统的材料作为慢性神经界面

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Engineered systems that can serve as chronically stable, high-performance electronic recording and stimulation interfaces to the brain and other parts of the nervous system, with cellular-level resolution across macroscopic areas, are of broad interest to the neuroscience and biomedical communities. Challenges remain in the development of biocompatible materials and the design of flexible implants for these purposes, where ulimate goals are for performance attributes approaching those of conventional wafer-based technologies and for operational timescales reaching the human lifespan. This Review summarizes recent advances in this field, with emphasis on active and passive constituent materials, design architectures and integration methods that support necessary levels of biocompatibility, electronic functionality, long-term stable operation in biofluids and reliability for use in vivo. Bioelectronic systems that enable multiplexed electrophysiological mapping across large areas at high spatiotemporal resolution are surveyed, with a particular focus on those with proven chronic stability in live animal models and scalability to thousands of channels over human-brain-scale dimensions. Research in materials science will continue to underpin progress in this field of study.
机译:能够作为宏观系统的大脑和其他部位的脑部和其他部位具有慢性稳定,高性能的电子记录和刺激接口的工程化系统,对宏观区域的细胞水平分辨率具有广泛的兴趣。挑战仍然存在于生物相容性材料的发展和用于这些目的的柔性植入物的设计,其中ulime目标是用于接近基于常规晶圆的技术的性能属性以及用于达到人类寿命的操作时间尺度的性能属性。本综述总结了该领域的最新进展,重点是主动和被动组成材料,设计架构和集成方法,支持生物相容性,电子功能,生物流体中的生物流通功能的必要水平,以及在体内使用的可靠性。调查了在高时的大区域实现多路复用电生理学映射的生物电子系统,特别关注那些在现场动物模型中经过验证的慢性稳定性的人和数千个渠道的可扩展性。材料科学研究将继续在这一研究领域进展。

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