Fine-needle aspiration cytology (FNAC) has traditionally been regarded as the simplest, less invasive, and less expensive diagnostic procedure for the definition of breast lesions [Khemka et al. 2009; Saha et al. 2016; Wang et al., 2017]. In expert hands, it allows obtaining an accurate diagnosis in most breast lesions. The introduction of widespread mam-mographic screening programs and the consequent detection of a large number of small, nonpalpable lesions have increasingly established the routine use of other minimally invasive biopsy methods using heavier gauge cutting needles-core needle biopsies (CNBs) and other automatic, im-aging-guided devices, such as vacuum-assisted biopsies-partially obscuring the central role of FNA [Brancato et al., 2012; Tabbara et al., 2000]. These new opportunities lead to a greater autonomy of the radiologists, who do not feel anymore the need of having the on-site cytopathologist attending the sampling session. Indeed, this professional is not always available in the "spoke" health care centers, although it is an indispensable element for the rapid on-site evaluation of sample adequacy and the "fast-track" diagnostic process. For this reason, CNB, previously considered as a second-level examination, available in cases with inadequate (C1) or indeterminate (C3-C4) cytology, has increasingly been used as a primary diagnostic method without resorting to cytology.
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