Sustained Viral Response in Genotype 4 Chronic Hepatitis C Virus-infected Children and Adolescents Treated With Sofosbuvir/Ledipasvir

El-Karaksy Hanaa; Mogahed Engy Adel; Abdullatif Hala; Ghobrial Carolyne; El-Raziky Mona S.; El-Koofy Nehal; El-Shabrawi Mortada; Ghita Haytham; Baroudy Sherif; Okasha Sawsan

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Sustained Viral Response in Genotype 4 Chronic Hepatitis C Virus-infected Children and Adolescents Treated With Sofosbuvir/Ledipasvir

机译：基因型4持续的病毒反应4慢性丙型肝炎病毒感染的儿童和青少年与Sofosbuvir / Leedipasvir治疗

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Objectives: Recently, direct acting antivirals (DAAs), sofosbuvir (SOF) combined with ledipasvir (LED), were approved for treatment of hepatitis C virus (HCV)-infected children 12 years of age and older or weighting at least 35 kg for all HCV genotypes. The aim of this study was to assess the safety and efficacy of SOF/LED in genotype 4 HCV-infected Egyptian children and adolescents.

机译：目的：最近，直接代理抗病毒（DAAS），Sofosbuvir（SOF）与LEDIPASVIR（LED）相结合，被批准用于治疗丙型肝炎病毒（HCV） - 12岁及以上或加权至少35公斤的乙型肝炎病毒（HCV）。 HCV基因型。本研究的目的是评估SOF / LED在基因型4 HCV感染的埃及儿童和青少年的安全性和有效性。

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来源
《Fortschritte der Physik》 |2018年第5期|共5页
作者
El-Karaksy Hanaa; Mogahed Engy Adel; Abdullatif Hala; Ghobrial Carolyne; El-Raziky Mona S.; El-Koofy Nehal; El-Shabrawi Mortada; Ghita Haytham; Baroudy Sherif; Okasha Sawsan;
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作者单位

Cairo Univ Kasr Alainy Med Sch Dept Pediat Cairo Egypt;

Cairo Univ Kasr Alainy Med Sch Dept Pediat Cairo Egypt;

Cairo Univ Kasr Alainy Med Sch Dept Pediat Cairo Egypt;

Cairo Univ Kasr Alainy Med Sch Dept Pediat Cairo Egypt;

Cairo Univ Kasr Alainy Med Sch Dept Pediat Cairo Egypt;

Cairo Univ Kasr Alainy Med Sch Dept Pediat Cairo Egypt;

Cairo Univ Kasr Alainy Med Sch Dept Pediat Cairo Egypt;

Cairo Univ Kasr Alainy Med Sch Dept Pediat Cairo Egypt;

Cairo Univ Kasr Alainy Med Sch Dept Pediat Cairo Egypt;

Cairo Univ Kasr Alainy Med Sch Dept Pediat Cairo Egypt;

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原文格式 PDF
正文语种 eng
中图分类物理学;
关键词
adolescents; children; hepatitis C virus; ledipasvir; sofosbuvir; sustained virological response;

机译：青少年;儿童;丙型肝炎病毒;LEDIPASVIR;SOFOSBUVIR;持续的病毒学反应;

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专利

1. Sustained Viral Response in Genotype 4 Chronic Hepatitis C Virus-infected Children and Adolescents Treated With Sofosbuvir/Ledipasvir [J] . El-Karaksy Hanaa, Mogahed Engy Adel, Abdullatif Hala, Journal of pediatric gastroenterology and nutrition . 2018,第5期

机译：基因型4持续的病毒反应4慢性丙型肝炎病毒感染的儿童和青少年与Sofosbuvir / Leedipasvir治疗
2. Sustained virologic response rates in patients with chronic hepatitis C genotype 6 treated with ledipasvir plus sofosbuvir or sofosbuvir plus velpatasvir [J] . Nguyen Emily, Trinh Sam, Huy Trinh, Alimentary pharmacology & therapeutics. . 2019,第1期

机译：用LEDIPASVIR加上Sofosbuvir或Sofosbuvir Plus Velpatasvir治疗慢性丙型肝炎基因型6患者的病毒性反应率
3. The Impact of Concomitant Acid Reducing Therapy (ART) on Sustained Virologic Response (SVR-12) Among Genotype 1 Infected Chronic Hepatitis C (CHC) Patients Treated with Ledipasvir/Sofosbuvir (LDV/SOF) With or Without Ribavirin [J] . Spoutz Patrick, Schaefer Monica, Pandya Prashant K., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2016,第S1期

机译：伴随酸还原疗法（ART）对基因型1感染慢性丙型肝炎（CHC）持续的病毒性反应（SVR-12）对莱普斯韦/ Sofosbuvir（LDV / SOF）的持续病毒性反应（SVR-12）的影响，有或没有利巴韦林
4. Genotype and Serotype Identification of Hepatitis B Virus in Chronic Hepatitis B Patients Treated with Telbivudine [C] . Y Purnamasari, Tien, Arimaswati, International Seminar on Smart Molecule of Natural Resources . 2020

机译：临床治疗慢性乙型肝炎患者乙型肝炎病毒的基因型和血清型鉴定
5. Ribavirin systemic and intracellular exposure and its role on viral response and anemia in chronic hepatitis c genotype 1 infection [D] . Wu, Liviawati Sutjandra. 2015

机译：利巴韦林全身和细胞内暴露及其在慢性丙型肝炎基因型1感染中对病毒反应和贫血的作用
6. The predictors of sustained virological response with sofosbuvir and ribavirin in patients with chronic hepatitis C genotype 2 [O] . Sung Yong Han, Hyun Young Woo, Jeong Heo, 2021

机译：慢性丙型肝炎患者患者Sofosbuvir和利巴韦林持续病毒学反应的预测因子2
7. Erratum to: SD1000: High Sustained Viral Response Rate in 1361 Patients With Hepatitis C Genotypes 1, 2, 3, and 4 Using a Low-cost Fixed-dose Combination Tablet of Generic Sofosbuvir and Daclatasvir: A Multicenter Phase III Clinical Trial [O] . Shahin Merat, Amir-Houshang Sharifi, Hossein Poustchi, 2021

机译：错误至：SD1000：1361名丙型肝炎患者患者的高持续病毒反应率1,2,3和4，使用通用Sofosbuvir和Daclatasvir的低成本固定剂量组合片剂：多中心期III临床试验

Sustained Viral Response in Genotype 4 Chronic Hepatitis C Virus-infected Children and Adolescents Treated With Sofosbuvir/Ledipasvir

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