3D Bioprinted Mini-Brains: A Glioblastoma Model to Study Cellular Interactions and Therapeutics

摘要

Glioblastoma-associated macrophages (GAMs) play a crucial role in the progression, invasion and chemoresistance of glioblastoma multiforme, a lethal form of brain tumor. However, so far, the cellular interactions between GAMs and tumor cells are not yet fully understood and current models are limited to pinpoint this exact interaction in a biologically relevant environment. Here we developed a novel 3D in vitro model using 3D bioprinting as an innovative way to study biological interactions between cells as well as response to cancer therapy similar to the clinical situation.