Reply to comment on ' Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration' by Luhmann et al. (Exp. Eye Res. 107, February 2013, 80-87)

摘要

They are concerned we imply that their Cx3crl~(GFP/CFP) or Cx3crl~'" mouse lines might carry the rd8 mutation. In our study, we did not assert that the Cx3crl~(GFP/GFP) and Cx3crl~h mouse lines studied by Combadiere et al. Q Clin Invest 2007; 117(10): 2920 or Chinnery et al., Neurobiol Aging 2012; 33(8):1769) carry the rd8 mutation, because we know by personal communication that they do not. Nevertheless we raised the general question, 'whether the previously reported pheno-type of different chemokine single knockout mice might also have been affected by the rd.8 mutation.', since there are other reports in the literature describing single chemokine knockout mice where this is not clear.