Classification of Ovarian Cancer:A Genomic Analysis

摘要

Ovarian cancer is the most lethal gynecologic cancer, accounting for over 16,000 deaths. In the US annually (1). The poor prognosis of this disease is due to the lack of reliable screening tools, the late stage of disease at the time of diagnosis, the high rate of recurrence of the disease, and the poor response to chemotherapy in the recurrent setting. Patients who present with stage I disease have over 90% 5-year survival, while those diagnosed with stage III disease have less than 20% 5-year survival (2). However, only 25% of patients with ovarian cancer are diagnosed with stage I disease (1). Despite new chemotherapeutic regimens and radical surgical debulking procedures, only minimal improvement in overall survival has been appreciated in the last several decades#