Cytological and cytogenetic approaches to diagnosis of primary intrapelvic Burkitt lymphoma involving the urinary bladder

摘要

Primary genitourinary lymphomas are uncommon and, in particular, primary bladder involvement by Burkitt lymphoma is extremely rare.Since this lymphoma is one of the most rapidly proliferating neoplasms and is often associated with a tumour lysis syndrome, prompt diagnosis is required. Although histopathological studies are absolutely necessary for diagnosis, cytology could be a beneficial ancillary method, providing more detailed information to clinicians. We recently encountered a case of Burkitt lymphoma involving the urinary bladder, which was initially evaluated by cytomorphological examination of a voided urine sample. The c-MYC/IgH gene translocation of tumour cells was confirmed by fluorescence in situ hybridization (FISH) methodology using the voided urine sample prepared for cytodiag-nosis.