Comparative pharmacokinetics of diaveridine in pigs and chickens following single intravenous and oral administration

摘要

Comparative pharmacokinetic profiles of diaveridine following single intravenous and oral dose of 10mg/kg body weight in healthy pigs and chickens were investigated, respectively. Concentrations of diaveridine in plasma samples were determined using a validated high-performance liquid chromatography-ultraviolet (HPLC-UV) method. The concentration-time data were subjected to noncompartmental kinetic analysis by WinNonlin program. The corresponding pharmacokinetic parameters in pigs or chickens after single intravenous administration were as follows, respectively: t(1/2) (elimination half-life) 0.74 +/- 0.28 and 3.44 +/- 1.07h; V-d (apparent volume of distribution) 2.70 +/- 0.99 and 3.86 +/- 0.92L/kg; Cl-B (body clearance) 2.59 +/- 0.62 and 0.80 +/- 0.14L/h/kg; and AUC(0-) (area under the blood concentration vs. time curve) 4.11 +/- 1.13 and 12.87 +/- 2.60g.h/mL. The corresponding pharmacokinetic parameters in pigs or chickens after oral administration were as follows, respectively: t(1/2) 1.78 +/- 0.41 and 2.91 +/- 0.57h; C-max (maximum concentration) 0.43 +/- 0.24 and 1.45 +/- 0.57g/mL; T-max (time to reach C-max) 1.04 +/- 0.67 and 3.25 +/- 0.71h; and AUC(0-)1.33 +/- 0.55 and 9.28 +/- 2.69g.h/mL. The oral bioavailability (F) of diaveridine in pigs or chickens was determined to be 34.6% and 72.2%, respectively. There were significant differences between the pharmacokinetics profiles in these two species.