Minisola and colleagues [1] comment that two randomized control trials (RCTs) (Sanders et al. [2] and Smith et al. [3]) lack important information concerning the distribution of risk factors for falls (cognitive impairment, drug use, alcohol use, etc.) in the two arms. Sanders et al. reported that at baseline the prevalence of risk factors for falls and fractures as well as previous fractures since the age of 50 years were similar in the vitamin D and placebo groups. Smith et al. [4] reported that previous fractures were similar in the two groups. Since more than 90 % of fractures occur after a fall, it is highly unlikely that a difference in baseline prevalence of risk factors for falls existed in either study. Furthermore, participants in both studies were randomized only if mentally competent to participate.
展开▼
