A prospective phase I comparison of toxicity and cosmesis outcomes of single-fraction IORT and hypofractionated radiotherapy with IORT boost in early-stage breast cancer

摘要

Abstract Purpose Radiation therapy is proven to reduce local recurrence in patients with early-stage breast cancer. To reduce toxicity, treatment time, and improve accuracy, intraoperative radiation therapy was used as definitive treatment or as a boost. The study's objective was to compare the short-term toxicity and cosmesis of single-fraction (SF) IORT and hypofractionated radiotherapy with IORT boost (HfB) given as definitive treatment. Methods and Materials Between March 2011 and December 2013, 57 patients aged?91ears and 24 patients aged 4383ears (total n = 81) with Stage 0II were treated with SF or HfB (Mobetron, IntraOp Medical, Sunnyvale, CA). For SF treatment, 21輞 was delivered using 4.56 cm applicators with electron energies from 6 to 12鋏V. For HfB, an intraoperative boost of 10輞 was delivered using 47 cm applicators with energies from 4 to 12鋏V followed by whole-breast radiation with 40.5輞 over 15 fractions. Toxicity was assessed at 2eeks, 6 onths, and 12 onths per Radiation Therapy Oncology Group acute skin toxicity criteria and cosmesis. Results At 12 onths, SF and HfB were well tolerated by all patients with no Grade 3+oxicity. At 1ear, Grade-2 toxicity was resolved. Ninety-eight percent of SF patients and ninety percent of HfB patients had 01 grade toxicity. In the SF and HfB groups, 100% of patients had excellent or good cosmesis at 12-month followup interval. The SF exhibited a more favorable cosmesis with a higher percentage of excellent scores compared with HfB (80.4% vs. 45%; p ?0.0033). Conclusions After breast conservation surgery, SF or HfB may be an option for patients with early-stage breast cancer compared to conventional external beam radiotherapy.