PK/PD modeling to identify optimal binding affinity of an intravitreally administered anti-IL33 antibody to maintain target engagement in vitreous and retina for the treatment of AMD

Figueroa Isabel; Nakamura Gerald; Comps-Agrar Laetitia; Chan Joyce; Mai Elaine; Corpuz Racquel; Bevers Jack; Loyet Kelly; Campagne Menno Van Lookeren; Kamath Amrita

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PK/PD modeling to identify optimal binding affinity of an intravitreally administered anti-IL33 antibody to maintain target engagement in vitreous and retina for the treatment of AMD

机译：PK / PD模型以鉴定透模给药的抗IL33抗体的最佳结合亲和力，以维持在玻璃体和视网膜中的靶啮合进行治疗AMD

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来源
《Investigative ophthalmology & visual science 》 |2018年第9期| 共3页
作者
Figueroa Isabel; Nakamura Gerald; Comps-Agrar Laetitia; Chan Joyce; Mai Elaine; Corpuz Racquel; Bevers Jack; Loyet Kelly; Campagne Menno Van Lookeren; Kamath Amrita;
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作者单位

Genentech Inc Belmont MA USA;

Genentech Inc Belmont MA USA;

Genentech Inc Belmont MA USA;

Genentech Inc Belmont MA USA;

Genentech Inc Belmont MA USA;

Genentech Inc Belmont MA USA;

Genentech Inc Belmont MA USA;

Genentech Inc Belmont MA USA;

Genentech Inc Belmont MA USA;

Genentech Inc Belmont MA USA;

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原文格式 PDF
正文语种 eng
中图分类眼科学 ;
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专利

1. PK/PD modeling to identify optimal binding affinity of an intravitreally administered anti-IL33 antibody to maintain target engagement in vitreous and retina for the treatment of AMD [J] . Figueroa Isabel, Nakamura Gerald, Comps-Agrar Laetitia, Investigative ophthalmology & visual science . 2018 ,第9期

机译：PK / PD模型以鉴定透模给药的抗IL33抗体的最佳结合亲和力，以维持在玻璃体和视网膜中的靶啮合进行治疗AMD
2. Investigation of PK/PD relationship between an anti-ST2 antibody and soluble target using a target mediated drug disposition PK model [J] . Jiao Qun, Jiang Xiling, Han Chao, Journal of pharmacokinetics and pharmacodynamics . 2017 ,第Suppla期

机译：使用靶介导的药物处理PK模型对抗ST2抗体与可溶性靶标的PK / PD关系的研究
3. IBI302, a promising candidate for AMD treatment, targeting both the VEGF and complement system with high binding affinity in vitro and effective targeting of the ocular tissue in healthy rhesus monkeys [J] . Ren Xinyi, Li Jia, Xu Xianxing, Experimental Eye Research . 2016 ,第Null期

机译：IBI302，一种有望用于AMD治疗的候选药物，在体外以高结合亲和力靶向VEGF和补体系统，并有效靶向健康恒河猴的眼组织
4. Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys [O] . Weirong Wang, Xiaofeng Wang, Rajitha Doddareddy, 2014

机译：破译食蟹猴中单克隆抗体与其可溶性靶标之间相互作用的机械药代动力学/靶标参与/药效学（PK / TE / PD）建模
5. Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys [O] . Weirong Wang, Xiaofeng Wang, Rajitha Doddareddy, 2013

机译：机械药代动力学/靶啮合/药效学/药效学（PK / TE / PD）在单克隆抗体与其可溶性靶中解密相互作用的模拟，Cynomolgus猴子

PK/PD modeling to identify optimal binding affinity of an intravitreally administered anti-IL33 antibody to maintain target engagement in vitreous and retina for the treatment of AMD

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