Proteinuria and risk of acute kidney injury

摘要

In The Lancet, Matthew James and colleagues use a province-wide sample of nearly 1 million adult Canadians to show the independent association between estimated glomerular filtration rate (eGFR), proteinuria, and incidence of acute kidney injury. Moreover, they provide evidence to show that the risks of death and progression to end-stage renal disease that are associated with acute kidney injury vary with levels of eGFR and proteinuria. James and colleagues' study extends growing evidence supporting the importance of both eGFR and proteinuria or albuminuria to assess the risks and outcomes of kidney disease.