Patients with acute venous thromboembolism can be treated as safely and effectively with fixed-dose weight-adjusted unfractionated heparin as with low-molecular-weight heparin and the regimen is suitable for outpatient treatment,say researchers.The researchers compared the two regimens in 697 patients: unfractionated heparin was administered subcutaneously as an initial dose of 333U/kg followed by a fixed dose of 250U/kg every 12 hours (345 patients)and low-molecular-weight heparin (dalteparin or enoxaparin)was administered subcutaneously at a dose of lOOIU/kg every 12 hours (352 patients).Both treatments could be given outside hospital and were overlapped with three months of warfarin therapy.
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