Of the wide variety of clinical and pathological prognostic factors that have been proposed as important to assess the risk of death from RCC one of the most potentially attractive histological prognosticators may be TN because of its reported high prognostic value and the fact that it can be assessed at every routine pathological examination without additional cost. Several studies indicate that necrosis is strongly associated with other adverse features, such as high tumor grade and stage, and with worse recurrence and survival outcomes, although there is controversy over whether it serves as an independent prognostic factor as well as its individual contribution to predicting prognosis (reference 15 in article).
展开▼
