Dialkyltitanium-mediated titanation of conjugated 1,3-butadiynes and its coupling reactions with aldehydes:a facile synthesis of stereodefined enynes and trans-enynols

摘要

A highly efficient and convenient method for the selective titanation of 1,3-butadiynes using Ti(O~iPr)4/ ~nBuLi reagent has been developed.The method provided a facile synthesis of enynes and trans-enynols in a well-stereodefined manner.The organometallic chemistry of group 4 metal complexes with 1,3-butadiynes R(C ident to C)2R and polyynes R(C ident to C)_nR has attracted considerable attention owing to their fascinating structural features,their unique M-C bonding,and their unusual capacity to induce highly selective transformation reactions.