Mechanistic study of rhodium/xantphos-catalyzed methanol carbonylation

摘要

Rhodium/iodide catalysts modified with the xantphos ligand are active for the homogeneous carbonylation of methanol to acetic acid using either pure CO or CO/H_2. Residues from catalytic reactions contain a Rh(III) acetyl complex, [Rh(xantphos)(COMe)I_2] (1), which was isolated and crystallographically characterized. The xantphos ligand in 1 adopts a "pincer" κ~3-P,O,P coordination mode with the xanthene oxygen donor trans to the acetyl ligand. The same product was also synthesized under mild conditions from [Rh(CO)_2I]_2. Iodide abstraction from 1 in the presence of donor ligands (L = MeCN, CO) gives the cationic acetyl species [Rh(xantphos)(COMe)I(L)]~+, whereas in CH _2Cl_2 migratory CO deinsertion gives [Rh(xantphos)(Me)I(CO) ]~+ (4), which reacts with H_2 to liberate methane, as observed in catalytic reactions using syngas. A number of Rh(I) xantphos complexes have been synthesized and characterized. Oxidative addition of methyl iodide to the cation [Rh(xantphos)(CO)]~+ is very slow but can be catalyzed by addition of an iodide salt, via a mechanism involving neutral [Rh(xantphos)(CO)I] (6). IR spectroscopic data and DFT calculations for 6 suggest the existence in solution of conformers with different Rh-O distances. Kinetic data and activation parameters are reported for the reaction of 6 with MeI, which proceeds by methylation of the Rh center and subsequent migratory insertion to give 1. The enhancement of nucleophilicity arising from a Rh- - -O interaction is supported by DFT calculations for the S_N2 transition state. A mechanism for catalytic methanol carbonylation based on the observed stoichiometric reaction steps is proposed. A survey of ligand conformations in xantphos complexes reveals a correlation between P-M-P bite angle and M-O distance and division into two broad categories with bite angle <120° (cis) or >143° (trans).