Highly Enantioselective Organocatalytic α?Sulfenylation of Azlactones

摘要

The first asymmetric α-sulfenylation of azlactones with N-(sulfanyl)succinimides has been developed by using cinchona alkaloid-derived squaramide as a catalyst and 4 ? molecular sieves as an additive. The reaction conditions were suitable to 4-alkyl and benzyl-substituted azlactones as well as N- (benzyl/alkyl/arylthio)succinimides, affording adducts with high enantioselectivities (81?94% ee).