Intermolecular Mizoroki-Heck Reaction of Aliphatic Olefins with High Selectivity for Substitution at the Internal Position

摘要

The Mizoroki-Heck reaction generally refers to Pd-catalyzed C-C bond formation between organic (pseudo)halides and olefins. Today, it has become a powerful tool to prepare substituted olefins. A key issue in intermolecular Heck reactions is the control of the site where aryl groups insert into olefins. High regioselectivity can be easily achieved for olefins carrying substituents with a significant electronic difference at the two olefinic sites, such as acrylates and vinyl ethers.