Liquid Phase Amination of 1-Bromobutane under High Temperature and High Pressure

摘要

The amination of 1-bromobutane in an aqueous ammonia solution of 50 wt% ammonia using a high-pressure coiled-tube flow reactor was examined. The temperature range studied was from 343 to 403 K and the reaction pressure was 13 MPa. The major reaction products were n-butylamine and di-n-butylamine, but higher amines, such as tri-n-butylamine, were detected only in trace amounts. Based on a second order consecutive reaction model for the formation of n-butylamine and di-n-butylamine, the reaction rate of amination of 1-buomobutane was determined. Arrhenius parameters for the rate constant of the first reaction step to form n-butylamine were found to have an activation energy of 87.9 kJ/mol and pre-exponential factor 1.03 X 10~9 mol/(dm~3 s), and those for the econd reaction step to form di-n-butylamine were found to have the activation energy of 84.3 kJ/mol and pre-exponential factor of 4.30 X 10~9 mol/(dm~3 s).