Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection

摘要

Objective: To evaluate the interaction between serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and Helicolacter pylori (H. pylori) infection in patients with chronic gastritis and peptic ulcer. Methods: The serum levels of sICAM-1 in 205 patients with chronic gastric diseases were detected by ELISA method and the status of H. pylori was determined by histologic examination, RUT, ~(14)C -UBT, and serology. The sera obtained from 18 healthy volunteers served as controls. Results: The serum levels of sICAM-1 were significantly higher in patients with H. pylori positive than those of H. pylori negative (889.43 +- 32.52 ng/ml vs. 747.07 +- 30.45 ng/ml, P<0.05). The serum levels of sICAM-1 in patients with mild, moderate and severe infection of H. pylori were 841.68 +- 72.36 ng/ml, 905.43 +- 37.59 ng/ml and 1012.54 +- 49.34 ng/ml, respectively (P<0. 05). The serum levels of sICAM-1 proved to be significantly correlated with the density of H. pylori colonization in gastric mucosa (r_s = 0.316, P < 0.001). The serum levels of sICAM- 1 in patients with chronic gastritis and peptic ulcer were significantly higher than those in healthy controls (P<0. 05). Conclusions: These results indicated that H. pylori infection up regulates the expression of sICAM- 1.