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外文期刊>Journal of the Chemical Society of Pakistan
>Activity on Leishmania tropica of Metal Complexes with NNOO Tetradentate Schiff Base Ligand: Kinetic and Thermodynamic Studies from TG-DTA Analysis
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Activity on Leishmania tropica of Metal Complexes with NNOO Tetradentate Schiff Base Ligand: Kinetic and Thermodynamic Studies from TG-DTA Analysis
In the search for antileishmanial drug, tetradentate Schiff base ligand 2-{(E)-[(2-{[(Z)(2-hydroxyphenyl)methylidene]amino}phenyl)imino]methyl}phenol (H2L) was reacted with transition metal ions to yield the complexes of the composition ML [where M = Co (II), Ni (II), Cu (II), & Zn (II)]. The copper based compound 3 (IC50 = 5.857 mu M) showed activities even higher than the standard drug. TG and DTA analyses under static air in the temperature range 30-1000 degrees C were also observed for all the compounds. The TG-DTA analyses and the subsequent themodynamic and kinetic parameters calculated using the TG-DTA curves, have potential relevance for the biological activities. Horowitz-Metzger method was applied for calculating the activation energies and order of pyrolysis. Thermodynamic parameters like Delta S*, Delta H* and Delta G* were subsequently calculated using the corresponding expressions. The order of decreasing thermal stability and decreasing activation energy follow the orders Ni(II) >Co(II)>Zn(II)>Cu(II) and E-Cu*>E-Co*>E-Ni*>E-Zn*, respectively.
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机译:在寻找抗衰老药物时,四齿席夫碱配体2-{(E)-[(2-{[((Z)(2-羟基苯基)亚甲基]氨基}苯基)亚氨基]甲基}苯酚(H2L)反应金属离子产生组成ML的配合物[其中M = Co(II),Ni(II),Cu(II)和Zn(II)]。铜基化合物3(IC50 = 5.857μM)的活性甚至高于标准药物。还观察到所有化合物在30-1000摄氏度温度范围内的静态空气下进行TG和DTA分析。 TG-DTA分析以及随后使用TG-DTA曲线计算出的热力学和动力学参数与生物活性具有潜在的相关性。应用Horowitz-Metzger方法计算活化能和热解级数。随后使用相应的表达式计算热力学参数,例如Delta S *,Delta H *和Delta G *。热稳定性降低和活化能降低的顺序依次为Ni(II)> Co(II)> Zn(II)> Cu(II)和E-Cu *> E-Co *> E-Ni *> E- Zn *。
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