PREDICTING THE EFFECT OF CYP3A INDUCERS ON THE PHARMACOKINETICS OF SUBSTRATE DRUGS USING PBPK MODELING - AN ANALYSIS OF PBPK SUBMISSIONS TO THE FDA

Wagner C.; Pan Y.; Hsu V.; Sinha V.; Zhao P.

首页> 外文期刊>Clinical Pharmacology and Therapeutics >PREDICTING THE EFFECT OF CYP3A INDUCERS ON THE PHARMACOKINETICS OF SUBSTRATE DRUGS USING PBPK MODELING - AN ANALYSIS OF PBPK SUBMISSIONS TO THE FDA

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PREDICTING THE EFFECT OF CYP3A INDUCERS ON THE PHARMACOKINETICS OF SUBSTRATE DRUGS USING PBPK MODELING - AN ANALYSIS OF PBPK SUBMISSIONS TO THE FDA

机译：使用PBPK模型预测CYP3A诱导剂对基质药物的药代动力学的影响-PBPK提交给FDA的分析

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来源
《Clinical Pharmacology and Therapeutics》 |2016年第1期|共2页
作者
Wagner C.; Pan Y.; Hsu V.; Sinha V.; Zhao P.;
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正文语种 eng
中图分类药理学;
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1. Predicting the Effect of CYP3A Inducers on the Pharmacokinetics of Substrate Drugs Using Physiologically Based Pharmacokinetic (PBPK) Modeling: An Analysis of PBPK Submissions to the US FDA [J] . Wagner Christian, Pan Yuzhuo, Hsu Vicky, Clinical pharmacokinetics . 2016,第4期

机译：使用基于生理学的药代动力学（PBPK）建模预测CYP3A诱导剂对底物药物的药代动力学的影响：PBPK提交给美国FDA的分析
2. PREDICTIVE PERFORMANCE OF PHYSIOLOGICALLY BASED PHARMACOKINETC (PBPK) MODELS FOR THE EFFECT OF CYP 3A INDUCERS ON SUBSTRATE DRUGS: ANALYSIS OF SUBMISSIONS TO THE FDA. [J] . Wagner C., Pan Y., Hsu V., Clinical Pharmacology and Therapeutics . 2015,第S1期

机译：基于CYP 3A诱导剂对基质药物的影响的基于生理的药动学（PBPK）模型的预测性能：提交FDA的分析。
3. PREDICTIVE PERFORMANCE OF PHYSIOLOGICALLY BASED PHARMACOKINETC (PBPK) MODELS FOR THE EFFECT OF CYP 3A INDUCERS ON SUBSTRATE DRUGS: ANALYSIS OF SUBMISSIONS TO THE FDA. [J] . Wagner C., Pan Y., Hsu V., Clinical Pharmacology and Therapeutics . 2015,第S1期

机译：基于CYP 3A诱导剂对基质药物的影响的基于生理的药动学（PBPK）模型的预测性能：提交FDA的分析。
4. Application of physiologically based pharmacokinetic (PBPK) modeling to predict the distribution of trichloroethylene in different tissues of young male rats [C] . Sattar K.Alcasey, Elise M.Westmeyer, Jane Ellen Simmons, Bioengineering conference . 1999

机译：生理药代动力学（PBPK）模型在预测三氯乙烯在年轻雄性大鼠不同组织中的分布中的应用
5. Mechanistic Physiologically Based Pharmacokinetic (PBPK) Modeling of Renal and Systemic Disposition of Drugs and Metabolites [D] . Huang, Weize. 2020

机译：基于机械生理学的药代动力学（PBPK）肾脏肾和药物分配的建模
6. A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction [O] . A B Ke, S C Nallani, P Zhao, 2012

机译：预测孕妇中CYP3A代谢药物处置的PBPK模型：验证和识别CYP3A诱导位点
7. USING SEMIPHYSIOLOGICALLY-BASED PHARMACOKINETIC (SEMI-PBPK) MODELING TO EXPLORE THE IMPACT OF DIFFERENCES BETWEEN THE INTRAVENOUS (IV) AND ORAL (PO) ROUTE OF ADMINISTRATION ON THE MAGNITUDE AND TIME COURSE OF CYP3A-MEDIATED METABOLIC DRUG-DRUG INTERACTIONS (DDI) USING MIDAZOLAM (MDZ) AS PROTOTYPICAL SUBSTRATE AND FLUCONAZOLE (FLZ) AND ERYTHROMYCIN (ERY) AS PROTOTYPICAL INHIBITORS [O] . Li Mengyao 2016

机译：使用基于半生理学的药代动力学（SEMI-PBPK）模型来探讨静脉（IV）和口服（PO）给药途径对经CYP3A药物代谢药物治疗（药物）的幅度和时间过程的影响咪达唑仑（MDZ）作为原型基质，氟康唑（FLZ）和红霉素（ERY）作为原型抑制剂

PREDICTING THE EFFECT OF CYP3A INDUCERS ON THE PHARMACOKINETICS OF SUBSTRATE DRUGS USING PBPK MODELING - AN ANALYSIS OF PBPK SUBMISSIONS TO THE FDA

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