PREPARATION OF UNSYMMETRICAL 1,4-BIS[2-ETHYNYL-3-THIENYL]BENZENE DERIVATIVE

摘要

Unsymmetrically substituted 1,4-bis(2-ethynyl-3-thienyl)benzene derivative was prepared,utilizing 1-bromo-4-(2-iodo-3-thienyl)benzene and 5-alkyl-3-bromo-2-ethynylthiophene derivatives as key intermediates.Molecular architectures have attracted current interest. Some of them are so called bio-mimetic or bio-inspired molecules,which resemble(from particular point of view concerning to the structure and functionality)to bio-polymers such as peptides,proteins,and so on.In the course of our continuing research on developing novel phosphorus ligands such as DPCBT(Chart 1),one of the author(K.T.)was inspired by structures of metalloproteins and peptides. We then designed 1,4-bis(2-ethynyl-3-thienyl)arene spacers(Chart 1,hereafter abbreviated to the ETAr spacer;in the case of m=1,abbreviated to the ETB spacer)as promising and easily-tunable spacers and we prepared compounds 1-5,containing the ETB or ETAr spacer(Chart 2).