Treatment of Hepatocellular Carcinoma in Elderly Patients

摘要

Background/Aims: The aim of-this study was to compare the survival in elderly hepatocellular carcinoma tHCC) patients treated with curative modalities (radiofrequency ablation (RFA), percutaneous ethanol injection (PEIT) and surgery) to those treated with transcatheter arterial chemoembolization (TACE) and supportive care. Methodology: Medical records of patients, With FCC older than 75 years who had visited a single tertiary medical center from -January 2000 to December 2011 were reviewed (n = 58). Multivariable-adjusted hazard ratios (HR) for mortality with 95% confidence intervals (CI) were estimated using Cox proportional hazard models. Results: Twenty-nine patients were treated by TACE, 19 patients by supportive care, and 10 patients by curative treatment (four by PEIT, three surgery and three by RFA).Variables associated with in, hepatocellular; ; creased survival were better Child-Pugh class and lower Treatment TNM stage. Treatment with curative intent showed significant survival benefit compared to TACE (HR for mortality 0.10; 95% CI, 0.01-0.95). In a subgroup analysis among patients with resectable HCC, supportive care showed significantly worse survival over TACE (HR for mortality 6.47; 95% CI, 2.14-19.56) and curative intend (HR for mortality, 16.23; 95% CI, 1.92-136.83). Conclusions: Curative treatment seems to have a better survival benefit in comparison with other treatment modalities in elderly HCC patients.