Mast cell leukemia in a dog

摘要

Cutaneous mast cell tumors are common in dogs, but systemic involvement is rare. In these rare cases, however, neoplastic mast cells can appear in large numbers in the peripheral blood, giving rise to mast cell leukemia or systemic mastocytosis. In both cases, the liver, spleen and bone marrow are often infiltrated with mast cells. Mast cell leukemia originates in the bone marrow and is characterized by a diffuse bone marrow infiltration with mast cells. The present case report describes the resultsof the blood cell count (CBC), serum biochemical panel, autopsy, histopathology and immunohistology of a 14-year-old male Jack Russell terrier with mast cell leukemia without cutaneous involvement.