HEMATOLOGIC COMPLICATIONS OF DIABETES MELLITUS

摘要

Hematologic complications are common developments in diabetes mellitus. They include abnormalities in the function, morphology, and metabolism of erythrocytes (red blood cells [RBCs]), leukocytes, and platelets, as well as abnormalities in hemostasis and plasma proteins. Most complications result from long term hyperglycemia, whereas other complications are associated with ketoacidosis. Unlike diabetic complications in other organ systems, which may take years to develop and are irreversible, hematologic abnormalities may be detected early in the course of disease and usually can be diminished with effective metabolic control. Therefore, changes in blood cells and proteins are important even in diabetic dogs and cats in which the time course of the disease may be limited. Although hematologic abnormalities usually do not present as primary manifestations of diabetes, they may contribute to more severe problems, such as anemia, infection, and hypercoagulability. Some hematologic changes, such as glycosylated hemoglobin, are useful markers for monitoring blood glucose control.