Intensity-dependent activation of intracellular signalling pathways in skeletal muscle: role of fibre type recruitment during exercise.

摘要

Physical activity elicits physiological responses in skeletal muscle that result in a number of health benefits, in particular in diseases associated with peripheral metabolic dysfunction such as diabetes, heart failure or chronic obstructive pulmonary disease. These diseases have been associated with altered skeletal muscle metabolism and, in some cases, diminished ATP production, decreased mitochondrial content, and a higher proportion of type II fast glycolytic fibre. Exercise training is one intervention that can increase the percentage of oxidative fibres (type I, slow) and have a beneficial impact on these disease states. Several studies have compared the effects of continuous vs. interval training, and have determined that interval training may be the most effective exercise strategy to promote mitochondrial biogenesis and enhance muscle oxidative capacity.