PDE11A associations with asthma: results of a genome-wide association scan.

摘要

The results of 4 successful genome-wide association studies have been reported recently, yielding 4 distinct loci, 0RMDL3, CHI3L1, PDE4D, and DENNDIB,1'4 with the disparity in the results likely caused by differences in the phenotypes studied. In an attempt to dissect further the genetic network in complex asthmatic phenotypes, we investigated allergic asthma specifically defined in children at age 6 years. Cases were patients with allergic asthma with early-onset persistent asthma defined as having physician diagnosed asthma and wheeze at ages 1 and 6 years and asthma medication use and allergies as reported by the mother; controls were defined as those having no diagnosis of asthma or reactive airway disease and no symptoms at ages 1 or 6 years and no asthma meditation use and no allergies (see Definition of Cases and Controls section in the Online Repository at www. jacionline.org for additional recruitment details and Table El for demographic and phenotype data).