It is indeed a pleasure to be asked to comment on this important and excellent study that is both exciting and perplexing. This important study, drawn from the Olmsted County cohort, addresses the risk of erectile dysfunction in men with and without lower urinary tract symptoms (LUTS) and with and without exposure to alpha-blockers. The Olmsted County cohort is a powerful tool to address some of these issues that are otherwise not obtainable in the usual clinical context or by clinical trial or interventions.
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