海藻酸钠水凝胶用于治疗心肌梗死后心衰研究进展

摘要

海藻酸盐生物材料因其良好的生物相容性、抗血栓特性,温和的物理凝胶化过程,以及与细胞外基质相似的凝胶基质结构和硬度,被广泛应用于组织工程和再生医学.海藻酸盐生物材料可用于急性心肌梗死的心肌植入治疗,也可作为干细胞、生物活性分子和再生因子进入心脏的载体,具有促进心肌修复和组织重建的治疗潜力.%Alginate biomaterial is widely used in tissue engineering and regeneration result of its biocompatibility,nonthrombogenic feature,mild and physical gelation process and similarity of its hydrogel matrix texture and stiffness to that of extracellular matrix.In this view,we mainly depict various biomedical applications of alginate hydrogel,such as a supporting cardiac implant in patient after myocardial infraction(M1) and a vector for the controlled delivery and presentation of bioactive moleculars,regenerative factors and cardiac stem cells into the heart,which will reveal therapeutic potential of injectable acellular alginate implants in inhobiting the damaging process after MI,promoting myocardial repair and tissue remodeling.