The f/t-PSA ratio in diagnosis of in-patients and out-patients: a unitary cutoff value is not useful!

摘要

Purpose In the prostate specific antigen (PSA) range of 4–10 ng/ml after a negative digital rectal examination, the PSA value indicates a lack of specificity with a carcinoma detection rate of roughly 20%. To improve the biopsy/carcinoma ratio, the interdisciplinary consensus recommends free PSA (fPSA) measurement. This does not take into account the pre-analysis when the cutoff value is established for biopsy indication.