Investigations into the environmental fate and effects of iopromide (ultravist), a widely used iodinated X-ray contrast medium

摘要

Iodinated X-ray contrast media are pharmaceuticals which are biologically inert and metabolically stable during their passage through the body and are excreted almost completely within a day into waste water. They are not readily biodegradable. However, in a test system simulating sewage treatment, we were able to show that the model compound iopromide (N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-methoxyacetylamino-N-methyliso-phthalamide) was amen- able to primary degradation. The resulting degradation product (5-amino-N, N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- N-methyliso-phalamide) showed a faster photolysis than the parent compound.