Monte Carlo Analysis of Boron Neutron Capture Therapy for the Treatment of Breast Cancer, invited

摘要

Boron neutron capture therapy (BNCT) is a binary cancer treatment modality that has been under clinical investigation for the treatment of glioma and melanoma for over 50 years. It is based on the ~(10)B(n,α)~7Li reaction in which high energy, high LET particles are emitted upon absorption of a neutron by ~(10)B. While the research toward application of this treatment to glioma has been exhaustive, its application to other types of cancer has been limited. This work seeks to computationally determine the efficacy of BNCT for the treatment of HER-2+ breast cancers, which account for approximately 30% of all breast tumors. The proposed treatment method is based on the conjugation of a HER-2-specific monoclonal antibody (Trastuzumab) with boron-rich oligomeric phosphate diesters (OPDs). Trastuzumab is currently used in the treatment of HER-2+ breast tumors and OPDs are under investigation at UCLA for use in BNCT.