A NOVEL DIRECT BORON-MEDIATED SYNTHESIS OF CINNAMIC ACIDS FROM AROMATIC ALDEHYDES AND ALIPHATIC CARBOXYLIC ACIDS

摘要

Cinnamic acids have been prepared in 64-85% yields by a new direct synthesis from aromatic aldehydes and aliphatic carboxylic acids in the presence of anhydrous sodium tetraborate and lithium chloride, bases as pyridine (Py) and 4-dimethylaminopyridine (DMAP), and N-methyl-2-pyrolidinone (NMP) as solvent, at reflux (180-190℃), for 8-12 hours. Without sodium tetraborate-lithium chloride this reaction is not possible.