Over beer and coffee, in labs and at scientific conferences, the speculation has been intense for years: Who in the RNA interference (RNAi) field, biologists wondered, would win the Nobel Prize, and when? Science's ultimate accolade was considered increasingly inevitable as the gene-silencing method revolutionized genetics, spurred development of new medical treatments, and transformed our understanding of cellular behavior. But, under Nobel rules, the prize can go to no more than three people. Yet many had made seminal contributions to the discovery and understanding of RNAi.
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