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摘要

Tumor metastases are a major cause of death from solid tumors. Evidence from preclinical models suggests that tumor cells do not metastasize alone but rather are assisted by specific host cells that modify the microenvironment of the target organ so that it can support the survival and growth of newly arriving tumor cells. Two independent studies of lung metastasis in mice converge on this theme. Kowanetz et al. show that tumor cells secrete granulocyte colony-stimulating factor, a protein that expands and mobilizes bone marrow cells of a specific type called Ly6G~+Ly6C~+ granu-locytes and facilitates their homing into the lung before the arrival of tumor cells.