Chromatin insulators are protein complexes that act to insulate portions of the genome from the powerful and potentially disruptive effects of transcriptional enhancers, which can activate the expression of genes across vast stretches of DNA. This barrier function of insulators allows them to demarcate transcrip-tional domains in chromatin. The Drosophila gypsy insulator complex consists of three core proteins: suppressor of Hairy wing [Su(Hw)], modifier of mdg4 [Mod(mdg4)], and centro-somal protein 190 (CP190).
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