Enantioselective Synthesis of Pactamycin, a Complex Antitumor Antibiotic

摘要

Complex organic molecules produced by bacteria have been used to treat numerous disease types for nearly a century (1-4). However, many naturally derived compounds that exhibit interesting bioactivities are practically inaccessible via synthetic organic chemistry. A natural product's structural complexity can create an insurmountable impediment to the preparation of analogs that might exhibit improved characteristics. An ongoing challenge in the field of synthetic chemistry is the development of methods that close the gap between the efficiency of bio-synthetic machinery and laboratory synthesis. Because of the inherent flexibility of the latter, success in this endeavor could provide access to useful structural variants that might otherwise be inaccessible.