As an oncologist,charles swanton too often has to tell his patients with advanced lung and breast cancer that their options are running out. That despite several different treatments, each somewhat successful at first, their tumors have grown back yet again, faster than ever. "It's as though tumors have this ability to guess what you are about to do next and preempt it," he laments. Swanton now thinks that he has evidence explaining how they might do that. When the research team he leads at Cancer Research UK's London Research Institute recently sequenced DNA taken from different parts of a patient's kidney tumor, the results did not agree. While several genetic changes
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