The Curious State of Iron in Enzymes that Oxidize

摘要

Iron(Ⅳ)-oxygen (fenyl) bonds are a crucial part of important enzymes such as the methane monooxygenase which converts methane to methanol, the ribonucleotide reductase which constructs the nucleotides for DNA, and the HIF prolyl hydroxylase which regulates the level of oxygen in tissue, ensuring it remains at an optimum level. There is also a ferryl unit at the heart of cytochrome P450 which metabolizes Pharmaceuticals as well as removing unwanted chemicals from the body.