Dermal bioaccessibility of plasticizers in indoor dust and clothing

摘要

Several studies indicate that human exposure to plasticizers via dermal pathway is not negligible, but the dermal bioaccessibility of phthalates and alternative plasticizers from the important environmental matrix including indoor dust and clothing and the importance weight of dermal exposure to those pollutants have been poorly studied. An in vitro physiologically based extraction test was employed to investigate the dermal bioaccessibility of target phthalates and alternative plasticizers from indoor dust and clothing. Temperature, incubation time, sweat/sebum ratio and solid/liquid ratio were selected to study their effects on the bioaccessibility. The bioaccessibility of Diethyl phthalates (DEP), dibutyl phthalate (DBP), bis-2-ethylhexyl phthalate (DEHP), Acetyl tributyl citrate (ATBC), bis-2-ethylhexyladipate (DEHA) and bis-2-ethylhexyl terephthalate (DEHT) in indoor dust were 66.20 +/- 1.93%, 94.27 +/- 131%, 80.37 +/- 8.09%, 75.02 +/- 2.12%, 94.50 +/- 3.42% and 74.09 +/- 3.79%, respectively, under the condition of 1:1 sweat/sebum ratio, 1/100 solid/liquid ratio (indoor dust), 1:1 area/area ratio (1:1, clothing) and 90 min incubation time at 36.3 degrees C which are chosen based on the experimental results and human physical conditions. DBP showed the highest bioaccessibility in all samples. The time course of the plasticizer release was fitted to a first-order one-compartment model. DBP showed the highest release rate (k(1)) calculated from the model, which was consistent with the bioaccessibility result. Risk assessment indicated that dermal exposure of DBP was an important exposure route, accounting for about 21.58% of total intake, and indoor dust was an important exposure media when considering the dermal bioaccessibility. (C) 2019 Elsevier B.V. All rights reserved.