Drugs that don't mix

摘要

Nathan Seppa's article on the untoward effects of proton pump inhibitors on the blood thinner clopidogrel ("Popular acid blockers don't mix with anticlot-ting medication," SN: 3/28/09, p. 11) raises the question: Does the study suggest anything about the effect of PPIs on a daily dose of aspirin (81 milligrams)- also a blood thinner?rnThe authors of this study didn't investigate the effect ofheartburn drugs (PPIs such as Prilosec or Nexium) on aspirin's anticlotting action. Various small studies have failed to show a clear diminution of aspirin's anticlotting effect from the use of a PPI, though the results are somewhat mixed and that work is ongoing.