Discussion on AMR and Human Microbiome and Microbiome in Non-Communicable Diseases

摘要

The India-EMBO Symposium on Human Microbiome -Resistance and Disease was organized by National Institute of Biomedical Genomics, West Bengal in association with J. Craig Venter Institute, USA during November 9-12, 2019. As a part of this Symposium, in the Session 'Anti-microbial resistance and human microbiome', Dr B. Bhattacharjee, Ramanujan Fellow, NIBMG spoke on 'Taking a closer look at AMR carriage among hospitalized preterm neonates'. She aimed to find out what pathogens do to preterm neonates admitted to Sick neonatal care unit in hospitals with respiratory distress carry in their nares, and how much of antibiotic (Ab) resistance found in bacterial isolates from hospital effluents. She discussed about Gm-negative bacteria Acetobacter baumannii, Klebsiella pneumoniae and E. coli showing resistance against Meropenem (Mrp), Cefotaxime (Cft), 3rd gen Ciprofloxacin and to Colistin used as growth promoter in animal husbandry; non-susceptible isolates of bacteria tested against these Ab(s); E. coli having highest amount of resistance in hospital water; %age of resistance of these bacteria to Ab(s) and 3 different Beta-lactamase (bla) gene variants (genotypic expression); burden of Ab resistance in Indian neonates; nasal carriage of pathogens among neonates; Amikacin, Cft, Tazobactem and Mrp used for babies in SNCU; high levels of multidrug resistance shown by Acinobacter sp, E. coli, Enterobacter sp and Klebsiella sp to different Ab(s); bla profiles of different isolates; disinfectants used in hospitals to kill Klebsiella sp; biofilm associated infection in babies; Mrp-resistant Klebsiella isolates from nares of babies.