Red blood cell methotrexate polyglutamates emerge as a function of dosage intensity and route of administration during pulsen methotrexate therapy in rheumatoid arthritis

摘要

Objective. MTX is a prodrug producing anti-arthritic effects through a folylpolyglutamate synthase-mediated activation to MTX polyglutamates (MTXPGs). Our objective was to characterize the pharmacokinetics of intracellular MTXPGs and the factors associated with their accumulation in adult RA patients treated with MTX weekly.