Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibitionn of the P38 mitogen-activated protein kinase pathway

摘要

Objectives. To determine the effects and mechanism of action of lithium chloride (LiCl) on cartilage destruction induced by the pro-inflammatory cytokines IL-1, IL-1 + oncostatin M and TNF-α.